Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in mice

Hepcidin, the main regulator of iron homeostasis, is repressed when erythropoiesis is acutely stimulated by erythropoietin (EPO) to favor iron supply to maturing erythroblasts. Erythroferrone (ERFE) has been identified as the erythroid regulator that inhibits hepcidin in stress erythropoiesis. A pow...

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Bibliografiset tiedot
Julkaisussa:Blood
Päätekijät: Nai, Antonella, Rubio, Aude, Campanella, Alessandro, Gourbeyre, Ophélie, Artuso, Irene, Bordini, Jessica, Gineste, Aurélie, Latour, Chloé, Besson-Fournier, Céline, Lin, Herbert Y., Coppin, Hélène, Roth, Marie-Paule, Camaschella, Clara, Silvestri, Laura, Meynard, Delphine
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Hematology 2016
Aiheet:
Red Cells, Iron, and Erythropoiesis
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865590/
https://ncbi.nlm.nih.gov/pubmed/26755707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-11-681494
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