Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in mice

Hepcidin, the main regulator of iron homeostasis, is repressed when erythropoiesis is acutely stimulated by erythropoietin (EPO) to favor iron supply to maturing erythroblasts. Erythroferrone (ERFE) has been identified as the erythroid regulator that inhibits hepcidin in stress erythropoiesis. A pow...

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Bibliografiske detaljer
Udgivet i:Blood
Main Authors: Nai, Antonella, Rubio, Aude, Campanella, Alessandro, Gourbeyre, Ophélie, Artuso, Irene, Bordini, Jessica, Gineste, Aurélie, Latour, Chloé, Besson-Fournier, Céline, Lin, Herbert Y., Coppin, Hélène, Roth, Marie-Paule, Camaschella, Clara, Silvestri, Laura, Meynard, Delphine
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2016
Fag:
Red Cells, Iron, and Erythropoiesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865590/
https://ncbi.nlm.nih.gov/pubmed/26755707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-11-681494
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