MicroRNA-130a Is Up-regulated in Mouse Liver by Iron Deficiency and Targets the Bone Morphogenetic Protein (BMP) Receptor ALK2 to Attenuate BMP Signaling and Hepcidin Transcription

Systemic iron balance is controlled by the liver peptide hormone hepcidin, which is transcriptionally regulated by the bone morphogenetic protein (BMP)-SMAD pathway. In iron deficiency, liver BMP-SMAD signaling and hepcidin are suppressed as a compensatory mechanism to increase iron availability. Mi...

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Autores principales: Zumbrennen-Bullough, Kimberly B., Wu, Qifang, Core, Amanda B., Canali, Susanna, Chen, Wenjie, Theurl, Igor, Meynard, Delphine, Babitt, Jodie L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156078/
https://ncbi.nlm.nih.gov/pubmed/25002578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.577387
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