MicroRNA-130a Is Up-regulated in Mouse Liver by Iron Deficiency and Targets the Bone Morphogenetic Protein (BMP) Receptor ALK2 to Attenuate BMP Signaling and Hepcidin Transcription

Systemic iron balance is controlled by the liver peptide hormone hepcidin, which is transcriptionally regulated by the bone morphogenetic protein (BMP)-SMAD pathway. In iron deficiency, liver BMP-SMAD signaling and hepcidin are suppressed as a compensatory mechanism to increase iron availability. Mi...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Zumbrennen-Bullough, Kimberly B., Wu, Qifang, Core, Amanda B., Canali, Susanna, Chen, Wenjie, Theurl, Igor, Meynard, Delphine, Babitt, Jodie L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156078/
https://ncbi.nlm.nih.gov/pubmed/25002578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.577387
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker