MicroRNA-130a Is Up-regulated in Mouse Liver by Iron Deficiency and Targets the Bone Morphogenetic Protein (BMP) Receptor ALK2 to Attenuate BMP Signaling and Hepcidin Transcription

Systemic iron balance is controlled by the liver peptide hormone hepcidin, which is transcriptionally regulated by the bone morphogenetic protein (BMP)-SMAD pathway. In iron deficiency, liver BMP-SMAD signaling and hepcidin are suppressed as a compensatory mechanism to increase iron availability. Mi...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Zumbrennen-Bullough, Kimberly B., Wu, Qifang, Core, Amanda B., Canali, Susanna, Chen, Wenjie, Theurl, Igor, Meynard, Delphine, Babitt, Jodie L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2014
Pynciau:
Signal Transduction
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156078/
https://ncbi.nlm.nih.gov/pubmed/25002578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.577387
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