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Endothelial cells produce bone morphogenetic protein 6 required for iron homeostasis in mice

Bone morphogenetic protein 6 (BMP6) signaling in hepatocytes is a central transcriptional regulator of the iron hormone hepcidin that controls systemic iron balance. How iron levels are sensed to regulate hepcidin production is not known, but local induction of liver BMP6 expression by iron is propo...

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Bibliografische gegevens
Gepubliceerd in:Blood
Hoofdauteurs: Canali, Susanna, Zumbrennen-Bullough, Kimberly B., Core, Amanda B., Wang, Chia-Yu, Nairz, Manfred, Bouley, Richard, Swirski, Filip K., Babitt, Jodie L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2017
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5270389/
https://ncbi.nlm.nih.gov/pubmed/27864295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-06-721571
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