Conditional Deletion of Smad1 and Smad5 in Somatic Cells of Male and Female Gonads Leads to Metastatic Tumor Development in Mice

The transforming growth factor β (TGFβ) family has critical roles in the regulation of fertility. In addition, the pathogenesis of some human cancers is attributed to misregulation of TGFβ function and SMAD2 or SMAD4 mutations. There are limited mouse models for the BMP signaling SMADs (BR-SMADs) 1,...

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Bibliographic Details
Main Authors: Pangas, Stephanie A., Li, Xiaohui, Umans, Lieve, Zwijsen, An, Huylebroeck, Danny, Gutierrez, Carolina, Wang, Degang, Martin, James F., Jamin, Soazik P., Behringer, Richard R., Robertson, Elizabeth J., Matzuk, Martin M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2223289/
https://ncbi.nlm.nih.gov/pubmed/17967875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01404-07
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