Smad 1/5 and Smad 4 Expression Are Important for Osteoclast Differentiation

To investigate the necessity of the canonical BMP pathway during osteoclast differentiation, we created osteoclasts with a conditional gene deletion for Smad1 and Smad5 (SMAD1/5), or Smad4 using adenovirus expressing CRE recombinase (Ad-CRE). Reduction of either Smad4 or Smad1/5 expression resulted...

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Bibliographic Details
Published in:J Cell Biochem
Main Authors: Tasca, Amy, Stemig, Melissa, Broege, Aaron, Huang, Brandon, Davydova, Julia, Zwijsen, An, Umans, Lieve, Jensen, Eric D., Gopalakrishnan, Raj, Mansky, Kim C.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4431909/
https://ncbi.nlm.nih.gov/pubmed/25711193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.25092
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