Bone Morphogenetic Proteins Signal Via SMAD and Mitogen-activated Protein (MAP) Kinase Pathways at Distinct Times during Osteoclastogenesis

To investigate the role of bone morphogenetic protein (BMP) signaling in osteoclastogenesis in vivo, we eliminated BMPRII in osteoclasts by creating a BMPRII(fl/fl);lysM-Cre mouse strain. Conditional knock-out (cKO) mice are osteopetrotic when compared with WT controls due to a decrease in osteoclas...

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Detalhes bibliográficos
Main Authors: Broege, Aaron, Pham, Lan, Jensen, Eric D., Emery, Ann, Huang, Tsang-Hai, Stemig, Melissa, Beppu, Hideyuki, Petryk, Anna, O'Connor, Michael, Mansky, Kim, Gopalakrishnan, Raj
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873576/
https://ncbi.nlm.nih.gov/pubmed/24235143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.496950
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