Bone Morphogenetic Proteins Signal Via SMAD and Mitogen-activated Protein (MAP) Kinase Pathways at Distinct Times during Osteoclastogenesis

To investigate the role of bone morphogenetic protein (BMP) signaling in osteoclastogenesis in vivo, we eliminated BMPRII in osteoclasts by creating a BMPRII(fl/fl);lysM-Cre mouse strain. Conditional knock-out (cKO) mice are osteopetrotic when compared with WT controls due to a decrease in osteoclas...

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Autors principals: Broege, Aaron, Pham, Lan, Jensen, Eric D., Emery, Ann, Huang, Tsang-Hai, Stemig, Melissa, Beppu, Hideyuki, Petryk, Anna, O'Connor, Michael, Mansky, Kim, Gopalakrishnan, Raj
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873576/
https://ncbi.nlm.nih.gov/pubmed/24235143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.496950
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