BMP-SMAD Signaling Regulates Lineage Priming, but Is Dispensable for Self-Renewal in Mouse Embryonic Stem Cells

Naive mouse embryonic stem cells (mESCs) are in a metastable state and fluctuate between inner cell mass- and epiblast-like phenotypes. Here, we show transient activation of the BMP-SMAD signaling pathway in mESCs containing a BMP-SMAD responsive reporter transgene. Activation of the BMP-SMAD report...

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Bibliografske podrobnosti
izdano v:Stem Cell Reports
Main Authors: Gomes Fernandes, Maria, Dries, Ruben, Roost, Matthias S., Semrau, Stefan, de Melo Bernardo, Ana, Davis, Richard P., Ramakrishnan, Ramprasad, Szuhai, Karoly, Maas, Elke, Umans, Lieve, Abon Escalona, Vanesa, Salvatori, Daniela, Deforce, Dieter, Van Criekinge, Wim, Huylebroeck, Danny, Mummery, Christine, Zwijsen, An, Chuva de Sousa Lopes, Susana M.
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2015
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720007/
https://ncbi.nlm.nih.gov/pubmed/26711875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2015.11.012
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