BMP-SMAD Signaling Regulates Lineage Priming, but Is Dispensable for Self-Renewal in Mouse Embryonic Stem Cells

Naive mouse embryonic stem cells (mESCs) are in a metastable state and fluctuate between inner cell mass- and epiblast-like phenotypes. Here, we show transient activation of the BMP-SMAD signaling pathway in mESCs containing a BMP-SMAD responsive reporter transgene. Activation of the BMP-SMAD report...

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Pubblicato in:Stem Cell Reports
Autori principali: Gomes Fernandes, Maria, Dries, Ruben, Roost, Matthias S., Semrau, Stefan, de Melo Bernardo, Ana, Davis, Richard P., Ramakrishnan, Ramprasad, Szuhai, Karoly, Maas, Elke, Umans, Lieve, Abon Escalona, Vanesa, Salvatori, Daniela, Deforce, Dieter, Van Criekinge, Wim, Huylebroeck, Danny, Mummery, Christine, Zwijsen, An, Chuva de Sousa Lopes, Susana M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720007/
https://ncbi.nlm.nih.gov/pubmed/26711875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2015.11.012
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