STALK CELL PHENOTYPE DEPENDS ON INTEGRATION OF NOTCH AND SMAD1/5 SIGNALING CASCADES

Gradients of VEGF induce single endothelial cells to become leading tip cells of emerging angiogenic sprouts. Tip cells then suppress tip cell features in adjacent stalk cells via Dll4/Notch mediated lateral inhibition. We report here that Smad1/Smad5 mediated BMP signaling synergizes with Notch sig...

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Udgivet i:Dev Cell
Main Authors: Moya, Iván M., Umans, Lieve, Maas, Elke, Pereira, Paulo N. G., Beets, Karen, Francis, Annick, Sents, Ward, Robertson, Elizabeth J., Mummery, Christine L., Huylebroeck, Danny, Zwijsen, An
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4544746/
https://ncbi.nlm.nih.gov/pubmed/22364862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2012.01.007
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