Fascin1 empowers YAP mechanotransduction and promotes cholangiocarcinoma development

Mechanical forces control cell behavior, including cancer progression. Cells sense forces through actomyosin to activate YAP. However, the regulators of F-actin dynamics playing relevant roles during mechanostransduction in vitro and in vivo remain poorly characterized. Here we identify the Fascin1...

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Veröffentlicht in:Commun Biol
Hauptverfasser: Pocaterra, Arianna, Scattolin, Gloria, Romani, Patrizia, Ament, Cindy, Ribback, Silvia, Chen, Xin, Evert, Matthias, Calvisi, Diego F., Dupont, Sirio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8217270/
https://ncbi.nlm.nih.gov/pubmed/34155338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-02286-9
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