TARGETING β-CATENIN IN HEPATOCELLULAR CANCERS INDUCED BY CO-EXPRESSION OF MUTANT β-CATENIN AND K-RAS IN MICE

Recently we have shown that co-expression of hMet and mutant-β-catenin using sleeping beauty transposon/transposase leads to HCC in mice that represents around 10% of human HCC. In the current study, we investigate if Ras activation, which can occur downstream of Met signaling, is sufficient to caus...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Hepatology
Prif Awduron: Tao, Junyan, Zhang, Rong, Singh, Sucha, Poddar, Minakshi, Xu, Emily, Oertel, Michael, Chen, Xin, Ganesh, Shanthi, Abrams, Marc, Monga, Satdarshan P.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5397318/
https://ncbi.nlm.nih.gov/pubmed/27981621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28975
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