Nrf2 and β-catenin coactivation in hepatocellular cancer: Biological and therapeutic implications

BACKGROUND: Hepatocellular cancer (HCC) remains a major unmet clinical need. Although activating CTNNB1 mutations are seen in prominent subsets of HCC cases, these by themselves are insufficient for hepatocarcinogenesis. Co-expression of mutant CTNNB1 with clinically relevant co-occurrence has yield...

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Veröffentlicht in:Hepatology
Hauptverfasser: Tao, Junyan, Krutsenko, Yaketrina, Moghe, Akshata, Singh, Sucha, Poddar, Minakshi, Bell, Aaron, Oertel, Michael, Singhi, Aatur D., Geller, David, Chen, Xin, Lujambio, Amaia, Liu, Silvia, Monga, Satdarshan P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8326305/
https://ncbi.nlm.nih.gov/pubmed/33529367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.31730
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