Thyroid Hormone Receptor-β Agonist GC-1 Inhibits Met-β-Catenin–Driven Hepatocellular Cancer

The thyromimetic agent GC-1 induces hepatocyte proliferation via Wnt/β-catenin signaling and may promote regeneration in both acute and chronic liver insufficiencies. However, β-catenin activation due to mutations in CTNNB1 is seen in a subset of hepatocellular carcinomas (HCC). Thus, it is critical...

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Detalhes bibliográficos
Publicado no:Am J Pathol
Main Authors: Puliga, Elisabetta, Min, Qian, Tao, Junyan, Zhang, Rong, Pradhan-Sundd, Tirthadipa, Poddar, Minakshi, Singh, Sucha, Columbano, Amedeo, Yu, Jinming, Monga, Satdarshan P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5809589/
https://ncbi.nlm.nih.gov/pubmed/28807594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2017.07.005
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