Dual β-Catenin and γ-Catenin Loss in Hepatocytes Impacts Their Polarity through Altered Transforming Growth Factor-β and Hepatocyte Nuclear Factor 4α Signaling

Hepatocytes are highly polarized epithelia. Loss of hepatocyte polarity is associated with various liver diseases, including cholestasis. However, the molecular underpinnings of hepatocyte polarization remain poorly understood. Loss of β-catenin at adherens junctions is compensated by γ-catenin and...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Am J Pathol
Autores principales: Pradhan-Sundd, Tirthadipa, Liu, Silvia, Singh, Sucha, Poddar, Minakshi, Ko, Sungjin, Bell, Aaron, Franks, Jonathan, Huck, Ian, Stolz, Donna, Apte, Udayan, Ranganathan, Sarangarajan, Nejak-Bowen, Kari, Monga, Satdarshan P.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Investigative Pathology 2021
Materias:
Regular Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8132180/
https://ncbi.nlm.nih.gov/pubmed/33662348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2021.02.008
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares