Dual β-Catenin and γ-Catenin Loss in Hepatocytes Impacts Their Polarity through Altered Transforming Growth Factor-β and Hepatocyte Nuclear Factor 4α Signaling

Hepatocytes are highly polarized epithelia. Loss of hepatocyte polarity is associated with various liver diseases, including cholestasis. However, the molecular underpinnings of hepatocyte polarization remain poorly understood. Loss of β-catenin at adherens junctions is compensated by γ-catenin and...

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Detaylı Bibliyografya
Yayımlandı:Am J Pathol
Asıl Yazarlar: Pradhan-Sundd, Tirthadipa, Liu, Silvia, Singh, Sucha, Poddar, Minakshi, Ko, Sungjin, Bell, Aaron, Franks, Jonathan, Huck, Ian, Stolz, Donna, Apte, Udayan, Ranganathan, Sarangarajan, Nejak-Bowen, Kari, Monga, Satdarshan P.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Investigative Pathology 2021
Konular:
Regular Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8132180/
https://ncbi.nlm.nih.gov/pubmed/33662348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2021.02.008
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