Dual β-Catenin and γ-Catenin Loss in Hepatocytes Impacts Their Polarity through Altered Transforming Growth Factor-β and Hepatocyte Nuclear Factor 4α Signaling

Hepatocytes are highly polarized epithelia. Loss of hepatocyte polarity is associated with various liver diseases, including cholestasis. However, the molecular underpinnings of hepatocyte polarization remain poorly understood. Loss of β-catenin at adherens junctions is compensated by γ-catenin and...

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Foilsithe in:Am J Pathol
Main Authors: Pradhan-Sundd, Tirthadipa, Liu, Silvia, Singh, Sucha, Poddar, Minakshi, Ko, Sungjin, Bell, Aaron, Franks, Jonathan, Huck, Ian, Stolz, Donna, Apte, Udayan, Ranganathan, Sarangarajan, Nejak-Bowen, Kari, Monga, Satdarshan P.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Investigative Pathology 2021
Ábhair:
Regular Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8132180/
https://ncbi.nlm.nih.gov/pubmed/33662348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2021.02.008
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