Dual Catenin Loss in Murine Liver Causes Tight Junctional Deregulation and Progressive Intrahepatic Cholestasis

β-Catenin, the downstream effector of the Wnt signaling, plays important roles in hepatic development, regeneration and tumorigenesis. However, its role at hepatocyte adherens junctions (AJ) is relatively poorly understood, chiefly due to spontaneous compensation by γ-catenin. Here, we simultaneousl...

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Vydáno v:Hepatology
Hlavní autoři: Pradhan-Sundd, Tirthadipa, Zhou, Lili, Vats, Ravi, Jiang, An, Molina, Laura, Singh, Sucha, Poddar, Minakshi, Russell, Jacquelyn M, Stolz, Donna B, Oertel, Michael, Apte, Udayan, Watkins, Simon, Ranganathan, Sarangarajan, Nejak-Bowen, Kari N., Sundd, Prithu, Monga, Satdarshan Pal
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5893443/
https://ncbi.nlm.nih.gov/pubmed/29023813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29585
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