Dual Catenin Loss in Murine Liver Causes Tight Junctional Deregulation and Progressive Intrahepatic Cholestasis

β-Catenin, the downstream effector of the Wnt signaling, plays important roles in hepatic development, regeneration and tumorigenesis. However, its role at hepatocyte adherens junctions (AJ) is relatively poorly understood, chiefly due to spontaneous compensation by γ-catenin. Here, we simultaneousl...

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Detalhes bibliográficos
Publicado no:Hepatology
Main Authors: Pradhan-Sundd, Tirthadipa, Zhou, Lili, Vats, Ravi, Jiang, An, Molina, Laura, Singh, Sucha, Poddar, Minakshi, Russell, Jacquelyn M, Stolz, Donna B, Oertel, Michael, Apte, Udayan, Watkins, Simon, Ranganathan, Sarangarajan, Nejak-Bowen, Kari N., Sundd, Prithu, Monga, Satdarshan Pal
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5893443/
https://ncbi.nlm.nih.gov/pubmed/29023813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29585
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