The Hippo Effector Transcriptional Coactivator with PDZ-Binding Motif Cooperates with Oncogenic β-Catenin to Induce Hepatoblastoma Development in Mice and Humans

Hepatoblastoma (HB) is the most common pediatric liver tumor. Though Wnt/β-catenin and Hippo cascades are implicated in HB development, studies on crosstalk between β-catenin and Hippo downstream effector transcriptional coactivator with PDZ-binding motif (TAZ) in HB are lacking. Expression levels o...

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Udgivet i:Am J Pathol
Main Authors: Zhang, Shu, Zhang, Jie, Evert, Katja, Li, Xiaolei, Liu, Pin, Kiss, Andras, Schaff, Zsuzsa, Ament, Cindy, Zhang, Yi, Serra, Monica, Evert, Matthias, Chen, Nianyong, Xu, Feng, Chen, Xin, Tao, Junyan, Calvisi, Diego F., Cigliano, Antonio
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7322365/
https://ncbi.nlm.nih.gov/pubmed/32283103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2020.03.011
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