De Novo DNA Methylation at Imprinted Loci during Reprogramming into Naive and Primed Pluripotency

CpG islands (CGIs) including those at imprinting control regions (ICRs) are protected from de novo methylation in somatic cells. However, many cancers often exhibit CGI hypermethylation, implying that the machinery is impaired in cancer cells. Here, we conducted a comprehensive analysis of CGI methy...

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Bibliografiset tiedot
Julkaisussa:Stem Cell Reports
Päätekijät: Yagi, Masaki, Kabata, Mio, Ukai, Tomoyo, Ohta, Sho, Tanaka, Akito, Shimada, Yui, Sugimoto, Michihiko, Araki, Kimi, Okita, Keisuke, Woltjen, Knut, Hochedlinger, Konrad, Yamamoto, Takuya, Yamada, Yasuhiro
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Elsevier 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6524733/
https://ncbi.nlm.nih.gov/pubmed/31056481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2019.04.008
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