De Novo DNA Methylation at Imprinted Loci during Reprogramming into Naive and Primed Pluripotency

CpG islands (CGIs) including those at imprinting control regions (ICRs) are protected from de novo methylation in somatic cells. However, many cancers often exhibit CGI hypermethylation, implying that the machinery is impaired in cancer cells. Here, we conducted a comprehensive analysis of CGI methy...

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Bibliografske podrobnosti
izdano v:Stem Cell Reports
Main Authors: Yagi, Masaki, Kabata, Mio, Ukai, Tomoyo, Ohta, Sho, Tanaka, Akito, Shimada, Yui, Sugimoto, Michihiko, Araki, Kimi, Okita, Keisuke, Woltjen, Knut, Hochedlinger, Konrad, Yamamoto, Takuya, Yamada, Yasuhiro
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2019
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6524733/
https://ncbi.nlm.nih.gov/pubmed/31056481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2019.04.008
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