De Novo DNA Methylation at Imprinted Loci during Reprogramming into Naive and Primed Pluripotency

CpG islands (CGIs) including those at imprinting control regions (ICRs) are protected from de novo methylation in somatic cells. However, many cancers often exhibit CGI hypermethylation, implying that the machinery is impaired in cancer cells. Here, we conducted a comprehensive analysis of CGI methy...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Yagi, Masaki, Kabata, Mio, Ukai, Tomoyo, Ohta, Sho, Tanaka, Akito, Shimada, Yui, Sugimoto, Michihiko, Araki, Kimi, Okita, Keisuke, Woltjen, Knut, Hochedlinger, Konrad, Yamamoto, Takuya, Yamada, Yasuhiro
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6524733/
https://ncbi.nlm.nih.gov/pubmed/31056481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2019.04.008
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