Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development

De novo establishment of DNA methylation is accomplished by DNMT3A and DNMT3B. Here, we analyze de novo DNA methylation in mouse embryonic fibroblasts (2i-MEFs) derived from DNA-hypomethylated 2i/L ES cells with genetic ablation of Dnmt3a or Dnmt3b. We identify 355 and 333 uniquely unmethylated gene...

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Publicat a:Nat Commun
Autors principals: Yagi, Masaki, Kabata, Mio, Tanaka, Akito, Ukai, Tomoyo, Ohta, Sho, Nakabayashi, Kazuhiko, Shimizu, Masahito, Hata, Kenichiro, Meissner, Alexander, Yamamoto, Takuya, Yamada, Yasuhiro
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7314859/
https://ncbi.nlm.nih.gov/pubmed/32581223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16989-w
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