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Suppression of Intestinal Neoplasia by Deletion of Dnmt3b

Aberrant gene silencing accompanied by DNA methylation is associated with neoplastic progression in many tumors that also show global loss of DNA methylation. Using conditional inactivation of de novo methyltransferase Dnmt3b in Apc(Min/+) mice, we demonstrate that the loss of Dnmt3b has no impact o...

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Detalhes bibliográficos
Main Authors: Lin, Haijiang, Yamada, Yasuhiro, Nguyen, Suzanne, Linhart, Heinz, Jackson-Grusby, Laurie, Meissner, Alexander, Meletis, Konstantinos, Lo, Grace, Jaenisch, Rudolf
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1446955/
https://ncbi.nlm.nih.gov/pubmed/16581773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.8.2976-2983.2006
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