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Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing
Increased methylation of CpG islands and silencing of affected target genes is frequently found in human cancer; however, in vivo the question of causality has only been addressed by loss-of-function studies. To directly evaluate the role and mechanism of de novo methylation in tumor development, we...
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| Auteurs principaux: | , , , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Cold Spring Harbor Laboratory Press
2007
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2081977/ https://ncbi.nlm.nih.gov/pubmed/18056424 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1594007 |
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