Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing

Increased methylation of CpG islands and silencing of affected target genes is frequently found in human cancer; however, in vivo the question of causality has only been addressed by loss-of-function studies. To directly evaluate the role and mechanism of de novo methylation in tumor development, we...

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Main Authors: Linhart, Heinz G., Lin, Haijiang, Yamada, Yasuhiro, Moran, Eva, Steine, Eveline J., Gokhale, Sumita, Lo, Grace, Cantu, Erika, Ehrich, Mathias, He, Timothy, Meissner, Alex, Jaenisch, Rudolf
Formáid: Artigo
Teanga:Inglês
Foilsithe: Cold Spring Harbor Laboratory Press 2007
Ábhair:
Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2081977/
https://ncbi.nlm.nih.gov/pubmed/18056424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1594007
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