Mutagenicity of 5-aza-2′-deoxycytidine is mediated by the mammalian DNA methyltransferase
The cytosine analog 5-aza-2′-deoxycytidine has been used clinically to reactivate genes silenced by DNA methylation. In particular, patients with β-thalassemia show fetal globin expression after administration of this hypomethylating drug. In addition, silencing of tumor suppressor gene expression b...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1997
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20784/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9114051/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.9.4681 |
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