Suppression of Intestinal Neoplasia by Deletion of Dnmt3b

Aberrant gene silencing accompanied by DNA methylation is associated with neoplastic progression in many tumors that also show global loss of DNA methylation. Using conditional inactivation of de novo methyltransferase Dnmt3b in Apc(Min/+) mice, we demonstrate that the loss of Dnmt3b has no impact o...

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Autores principales: Lin, Haijiang, Yamada, Yasuhiro, Nguyen, Suzanne, Linhart, Heinz, Jackson-Grusby, Laurie, Meissner, Alexander, Meletis, Konstantinos, Lo, Grace, Jaenisch, Rudolf
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2006
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1446955/
https://ncbi.nlm.nih.gov/pubmed/16581773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.8.2976-2983.2006
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