Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development

De novo establishment of DNA methylation is accomplished by DNMT3A and DNMT3B. Here, we analyze de novo DNA methylation in mouse embryonic fibroblasts (2i-MEFs) derived from DNA-hypomethylated 2i/L ES cells with genetic ablation of Dnmt3a or Dnmt3b. We identify 355 and 333 uniquely unmethylated gene...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nat Commun
Hauptverfasser: Yagi, Masaki, Kabata, Mio, Tanaka, Akito, Ukai, Tomoyo, Ohta, Sho, Nakabayashi, Kazuhiko, Shimizu, Masahito, Hata, Kenichiro, Meissner, Alexander, Yamamoto, Takuya, Yamada, Yasuhiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7314859/
https://ncbi.nlm.nih.gov/pubmed/32581223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16989-w
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge