Pervasive H3K27 acetylation leads to ERV expression and a therapeutic vulnerability in H3K27M gliomas

High-grade gliomas (HGG) defined by histone 3 K27M driver mutations exhibit global loss of H3K27 trimethylation and reciprocal gain of H3K27 acetylation, respectively shaping repressive and active chromatin landscapes. We generated tumor-derived isogenic models bearing this mutation and show that it...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Cancer Cell
Asıl Yazarlar: Krug, Brian, De Jay, Nicolas, Harutyunyan, Ashot S., Deshmukh, Shriya, Marchione, Dylan M., Guilhamon, Paul, Bertrand, Kelsey C., Mikael, Leonie G., McConechy, Melissa K., Chen, Carol CL, Khazaei, Sima, Koncar, Robert F., Agnihotri, Sameer, Faury, Damien, Ellezam, Benjamin, Weil, Alexander G., Ursini-Siegel, Josie, De Carvalho, Daniel D., Dirks, Peter B., Lewis, Peter W., Salomoni, Paolo, Lupien, Mathieu, Arrowsmith, Cheryl, Lasko, Paul F., Garcia, Benjamin A., Kleinman, Claudia L., Jabado, Nada, Mack, Stephen C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6521975/
https://ncbi.nlm.nih.gov/pubmed/31085178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.04.004
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller