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BCAP promotes lupus-like disease and TLR-mediated Type I IFN induction in plasmacytoid dendritic cells
Systemic lupus erythematosus (SLE) severity correlates with elevated serum levels of type I interferons (IFN), cytokines produced in large quantities by pDC in response to engagement of TLR7 and TLR9 with endocytosed nucleic acids. B cell adaptor for PI3K (BCAP) promoted many aspects of TLR7-driven...
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| Udgivet i: | J Immunol |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6516743/ https://ncbi.nlm.nih.gov/pubmed/30936294 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1801267 |
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