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BCAP promotes lupus-like disease and TLR-mediated Type I IFN induction in plasmacytoid dendritic cells

Systemic lupus erythematosus (SLE) severity correlates with elevated serum levels of type I interferons (IFN), cytokines produced in large quantities by pDC in response to engagement of TLR7 and TLR9 with endocytosed nucleic acids. B cell adaptor for PI3K (BCAP) promoted many aspects of TLR7-driven...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Chu, Talyn, Ni, Minjian, Chen, Chunmo, Akilesh, Shreeram, Hamerman, Jessica A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6516743/
https://ncbi.nlm.nih.gov/pubmed/30936294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1801267
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