Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation

Plasmacytoid dendritic cells (pDCs) play a key role in antiviral immunity, but also contribute to the pathogenesis of certain autoimmune diseases, by producing large amounts of type I IFNs. Although activation of pDCs is triggered by engagement of nucleotide-sensing toll-like receptors (TLR) 7 and 9...

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Detalhes bibliográficos
Main Authors: Gotoh, Kazuhito, Tanaka, Yoshihiko, Nishikimi, Akihiko, Nakamura, Risa, Yamada, Hisakata, Maeda, Naoyoshi, Ishikawa, Takahiro, Hoshino, Katsuaki, Uruno, Takehito, Cao, Qinhong, Higashi, Sadayuki, Kawaguchi, Yasushi, Enjoji, Munechika, Takayanagi, Ryoichi, Kaisho, Tsuneyasu, Yoshikai, Yasunobu, Fukui, Yoshinori
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2010
Assuntos:
Brief Definitive Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856018/
https://ncbi.nlm.nih.gov/pubmed/20231379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091776
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