BCAP promotes lupus-like disease and TLR-mediated Type I IFN induction in plasmacytoid dendritic cells

Systemic lupus erythematosus (SLE) severity correlates with elevated serum levels of type I interferons (IFN), cytokines produced in large quantities by pDC in response to engagement of TLR7 and TLR9 with endocytosed nucleic acids. B cell adaptor for PI3K (BCAP) promoted many aspects of TLR7-driven...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:J Immunol
Hlavní autoři: Chu, Talyn, Ni, Minjian, Chen, Chunmo, Akilesh, Shreeram, Hamerman, Jessica A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6516743/
https://ncbi.nlm.nih.gov/pubmed/30936294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1801267
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky