B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K

Toll-like receptors (TLRs) recognize pathogens and their components, thereby initiating immune responses to infectious organisms. TLR ligation leads to the activation of NF-κB and MAPKs through well-defined pathways, but it has remained unclear how TLR signaling activates PI3K, which provides an inh...

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Bibliografiske detaljer
Main Authors: Ni, Minjian, MacFarlane, Alexander W., Toft, Michelle, Lowell, Clifford A., Campbell, Kerry S., Hamerman, Jessica A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3252908/
https://ncbi.nlm.nih.gov/pubmed/22187458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111957108
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