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Dynamin‐like protein 1 cleavage by calpain in Alzheimer’s disease

Abnormal mitochondrial dynamics contributes to mitochondrial dysfunction in Alzheimer's disease (AD), yet the underlying mechanism remains elusive. In the current study, we reported that DLP1, the key mitochondrial fission GTPase, is a substrate of calpain which produced specific N‐terminal DLP...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Jiang, Sirui, Shao, Changjuan, Tang, Fangqiang, Wang, Wenzhang, Zhu, Xiongwei
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6516178/
https://ncbi.nlm.nih.gov/pubmed/30767411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12912
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