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Calpain-mediated cleavage of DARPP-32 in Alzheimer’s disease
Toxicity induced by aberrant protein aggregates in Alzheimer’s disease (AD) causes synaptic disconnection and concomitant progressive neurodegeneration that eventually impair cognitive function. cAMP-response element-binding protein (CREB) is a transcription factor involved in the molecular switch t...
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| Опубликовано в: : | Aging Cell |
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| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
John Wiley & Sons, Ltd
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4568975/ https://ncbi.nlm.nih.gov/pubmed/26178297 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12374 |
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