Calpain-mediated cleavage of DARPP-32 in Alzheimer’s disease

Toxicity induced by aberrant protein aggregates in Alzheimer’s disease (AD) causes synaptic disconnection and concomitant progressive neurodegeneration that eventually impair cognitive function. cAMP-response element-binding protein (CREB) is a transcription factor involved in the molecular switch t...

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Publicado en:Aging Cell
Autores principales: Cho, Kwangmin, Cho, Mi-Hyang, Seo, Jung-Han, Peak, Jongjin, Kong, Kyoung-Hye, Yoon, Seung-Yong, Kim, Dong-Hou
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley & Sons, Ltd 2015
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4568975/
https://ncbi.nlm.nih.gov/pubmed/26178297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12374
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