Design of a Short Thermally Stable α-Helix Embedded in a Macrocycle

Although helices play key roles in peptide–protein and protein–protein interactions, the helical conformation is generally unstable for short peptides (10–15 residues) in aqueous solution in the absence of their binding partners. Thus, stabilizing the helical conformation of peptides can lead to inc...

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Udgivet i:Chembiochem
Main Authors: Wu, Haifan, Acharyya, Arusha, Wu, Yibing, Liu, Lijun, Jo, Hyunil, Gai, Feng, DeGrado, William F.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6512792/
https://ncbi.nlm.nih.gov/pubmed/29417711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201800026
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