Cut-and-Run: A Distinct Mechanism by which V(D)J Recombination Causes Genome Instability

V(D)J recombination is essential to generate antigen receptor diversity but is also a potent cause of genome instability. Many chromosome alterations that result from aberrant V(D)J recombination involve breaks at single recombination signal sequences (RSSs). A long-standing question, however, is ho...

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Foilsithe in:Mol Cell
Main Authors: Kirkham, Christopher M., Scott, James N.F., Wang, Xiaoling, Smith, Alastair L., Kupinski, Adam P., Ford, Anthony M., Westhead, David R., Stockley, Peter G., Tuma, Roman, Boyes, Joan
Formáid: Artigo
Teanga:Inglês
Foilsithe: Cell Press 2019
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6509286/
https://ncbi.nlm.nih.gov/pubmed/30905508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.02.025
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