Stereoselective Oxidation Kinetics of Deoxycholate in Recombinant and Microsomal CYP3A Enzymes: Deoxycholate 19-Hydroxylation Is an In Vitro Marker of CYP3A7 Activity

The primary bile acids (BAs) synthesized from cholesterol in the liver are converted to secondary BAs by gut microbiota. It was recently disclosed that the major secondary BA, deoxycholate (DCA) species, is stereoselectively oxidized to tertiary BAs exclusively by CYP3A enzymes. This work subsequent...

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Publicado no:Drug Metab Dispos
Main Authors: Chen, Yu-Jie, Zhang, Jian, Zhu, Ping-Ping, Tan, Xian-Wen, Lin, Qiu-Hong, Wang, Wen-Xia, Yin, Shan-Shan, Gao, Ling-Zhi, Su, Ming-Ming, Liu, Chang-Xiao, Xu, Liang, Jia, Wei, Sevrioukova, Irina F., Lan, Ke
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2019
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6505377/
https://ncbi.nlm.nih.gov/pubmed/30918015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.119.086637
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