Continuum of Host-Gut Microbial Co-metabolism: Host CYP3A4/3A7 are Responsible for Tertiary Oxidations of Deoxycholate Species

The gut microbiota modifies endogenous primary bile acids (BAs) to produce exogenous secondary BAs, which may be further metabolized by cytochrome P450 enzymes (P450s). Our primary aim was to examine how the host adapts to the stress of microbe-derived secondary BAs by P450-mediated oxidative modifi...

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Detalhes bibliográficos
Publicado no:Drug Metab Dispos
Main Authors: Zhang, Jian, Gao, Ling-Zhi, Chen, Yu-Jie, Zhu, Ping-Ping, Yin, Shan-Shan, Su, Ming-Ming, Ni, Yan, Miao, Jia, Wu, Wen-Lin, Chen, Hong, Brouwer, Kim L. R., Liu, Chang-Xiao, Xu, Liang, Jia, Wei, Lan, Ke
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2019
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6378331/
https://ncbi.nlm.nih.gov/pubmed/30606729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.118.085670
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