Methadone N-demethylation in human liver microsomes: lack of stereoselectivity and involvement of CYP3A4

AIMS: To investigate the kinetics of CYP-mediated N-demethylation of methadone in human liver microsomes, and examine the role of stereoselectivity and CYP isoforms involved. METHODS: The kinetics of 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) formation via N-demethylation of rac-, (R)-...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Foster, David J R, Somogyi, Andrew A, Bochner, Felix
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 1999
Assuntos:
Drug Disposition
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014231/
https://ncbi.nlm.nih.gov/pubmed/10233205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1999.00921.x
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados