Identification of the cytochrome P450 enzymes involved in the N-demethylation of sildenafil

AIMS: To characterize the cytochrome P450 (CYP) enzymes responsible for the N-demethylation of sildenafil to its main metabolite, UK-103 320, to investigate the potential inhibitory effects of sildenafil on CYP enzymes and to evaluate the potential of selected drugs to affect sildenafil metabolism....

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Detalhes bibliográficos
Main Authors: Hyland, R, Roe, E G H, Jones, B C, Smith, D A
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2001
Assuntos:
Drug Disposition
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2015027/
https://ncbi.nlm.nih.gov/pubmed/11298070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2001.00318.x
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