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Identification of the cytochrome P450 enzymes involved in the N-demethylation of sildenafil
AIMS: To characterize the cytochrome P450 (CYP) enzymes responsible for the N-demethylation of sildenafil to its main metabolite, UK-103 320, to investigate the potential inhibitory effects of sildenafil on CYP enzymes and to evaluate the potential of selected drugs to affect sildenafil metabolism....
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Blackwell Science Inc
2001
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2015027/ https://ncbi.nlm.nih.gov/pubmed/11298070 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2001.00318.x |
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