Llwytho...

Cytochromes P450 mediating the N-demethylation of amitriptyline

Aims Using human liver microsomes and heterologously expressed human enzymes, we have investigated the involvement of CYPs 1A2, 2C9, 2C19, 2D6 and 3A4 in the N-demethylation of amitriptyline (AMI), with a view to defining likely influences on its clinical pharmacokinetics. Methods The kinetics of fo...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ghahramani, P., Ellis, S. W., Lennard, M. S., Ramsay, L. E., Tucker, G. T.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 1997
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2042727/
https://ncbi.nlm.nih.gov/pubmed/9131945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1997.05382.x
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