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Cytochromes P450 mediating the N-demethylation of amitriptyline
Aims Using human liver microsomes and heterologously expressed human enzymes, we have investigated the involvement of CYPs 1A2, 2C9, 2C19, 2D6 and 3A4 in the N-demethylation of amitriptyline (AMI), with a view to defining likely influences on its clinical pharmacokinetics. Methods The kinetics of fo...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
1997
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2042727/ https://ncbi.nlm.nih.gov/pubmed/9131945 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1997.05382.x |
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