Enzyme kinetic modelling as a tool to analyse the behaviour of cytochrome P450 catalysed reactions: application to amitriptyline N-demethylation

1To determine kinetic parameters (V(max), K(m)) for cytochrome P450 (CYP) mediated metabolic pathways, nonlinear least squares regression is commonly used to fit a model equation (e.g., Michaelis Menten [MM]) to sets of data points (reaction velocity vs substrate concentration). This method can also...

Full description

Saved in:
Bibliographic Details
Main Authors: SCHMIDER, JÜRGEN, GREENBLATT, DAVID J., HARMATZ, JEROLD S., SHADER, RICHARD I.
Format: Artigo
Language:Inglês
Published: 1996
Subjects:
Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2042612/
https://ncbi.nlm.nih.gov/pubmed/8799527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1996.35717.x
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items