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Kinetic Modeling of Steady-State Situations in Cytochrome P450 Enzyme Reactions

In the course of investigations of the kinetics of individual reactions of cytochrome P450 (P450) enzymes, a number of points about the complexity of P450 enzyme kinetics have become apparent. Several of these are of particular relevance to work with P450 enzymes in the course of drug development an...

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Detalhes bibliográficos
Publicado no:Drug Metab Dispos
Autor principal: Guengerich, F. Peter
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6815944/
https://ncbi.nlm.nih.gov/pubmed/31427434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.119.088732
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