Inhibition of cytochrome P450 by nefazodone in vitro: studies of dextromethorphan O- and N-demethylation

Nefazodone (NEF), a 5-HT(2A/2C) antagonist antidepressant, is extensively metabolized in the human body to hydroxy NEF (OH-NEF), p-hydroxy NEF (pOH-NEF), a dione metabolite, and via cleavage of the molecule to m-chlorophenyl-piperazine (mCPP) and BMY-33604. The latter is further metabolized to BMS-1...

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Detalhes bibliográficos
Main Authors: SCHMIDER, JÜRGEN, GREENBLATT, DAVID J., VON MOLTKE, LISA L., HARMATZ, JEROLD S., SHADER, RICHARD I.
Formato: Artigo
Idioma:Inglês
Publicado em: 1996
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2042592/
https://ncbi.nlm.nih.gov/pubmed/8730981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1996.30512.x
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