Zolpidem metabolism in vitro: responsible cytochromes, chemical inhibitors, and in vivo correlations

AIMS: To determine the human cytochromes mediating biotransformation of the imidazopyridine hypnotic, zolpidem, and the clinical correlates of the findings. METHODS: Kinetic properties of zolpidem biotransformation to its three hydroxylated metabolites were studied in vitro using human liver microso...

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Detalhes bibliográficos
Main Authors: von Moltke, Lisa L, Greenblatt, David J, Granda, Brian W, Duan, Su Xiang, Grassi, Jeffrey M, Venkatakrishnan, Karthik, Harmatz, Jerold S, Shader, Richard I
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 1999
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014868/
https://ncbi.nlm.nih.gov/pubmed/10383565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1999.00953.x
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