Role of NADPH-Cytochrome P450 Reductase and Cytochrome-b(5)/NADH-b(5) Reductase in Variability of CYP3A Activity in Human Liver Microsomes

NADPH-cytochrome P450 reductase (CPR) and cytochrome-b(5) (b(5)) together with NADH-b(5) reductase (b(5)R) play important roles in cytochrome P450 3A-mediated drug metabolism via electron transfer. However, it is not clear whether variability in expression of these accessory proteins contributes to...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Gan, Lu, von Moltke, Lisa L., Trepanier, Lauren A., Harmatz, Jerold S., Greenblatt, David J., Court, Michael H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Pharmacology and Experimental Therapeutics 2009
Assuntos:
Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2610240/
https://ncbi.nlm.nih.gov/pubmed/18838505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.108.023424
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados