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Role of NADPH-Cytochrome P450 Reductase and Cytochrome-b(5)/NADH-b(5) Reductase in Variability of CYP3A Activity in Human Liver Microsomes
NADPH-cytochrome P450 reductase (CPR) and cytochrome-b(5) (b(5)) together with NADH-b(5) reductase (b(5)R) play important roles in cytochrome P450 3A-mediated drug metabolism via electron transfer. However, it is not clear whether variability in expression of these accessory proteins contributes to...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Pharmacology and Experimental Therapeutics
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2610240/ https://ncbi.nlm.nih.gov/pubmed/18838505 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.108.023424 |
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