Reductive Detoxication of Arylhydroxylamine Carcinogens by Human NADH Cytochrome b(5) Reductase and Cytochrome b(5)

Heterocyclic and aromatic amine carcinogens are thought to lead to tumor initiation via the formation of DNA adducts, and bioactivation to arylhydroxylamine metabolites is necessary for reactivity with DNA. Carcinogenic arylhydroxylamine metabolites are cleared by a microsomal, NADH-dependent, oxyge...

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Hauptverfasser: Kurian, Joseph R., Chin, Nathaniel A., Longlais, Brett J., Hayes, Kristie L., Trepanier, Lauren A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2516554/
https://ncbi.nlm.nih.gov/pubmed/17040106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx060106t
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