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Reductive Detoxication of Arylhydroxylamine Carcinogens by Human NADH Cytochrome b(5) Reductase and Cytochrome b(5)

Heterocyclic and aromatic amine carcinogens are thought to lead to tumor initiation via the formation of DNA adducts, and bioactivation to arylhydroxylamine metabolites is necessary for reactivity with DNA. Carcinogenic arylhydroxylamine metabolites are cleared by a microsomal, NADH-dependent, oxyge...

詳細記述

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書誌詳細
主要な著者: Kurian, Joseph R., Chin, Nathaniel A., Longlais, Brett J., Hayes, Kristie L., Trepanier, Lauren A.
フォーマット: Artigo
言語:Inglês
出版事項: 2006
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2516554/
https://ncbi.nlm.nih.gov/pubmed/17040106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx060106t
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