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Cytochrome b(5) and NADH cytochrome b(5) reductase: genotype-phenotype correlations for hydroxylamine reduction
OBJECTIVES: NADH cytochrome b(5) reductase (b5R) and cytochrome b(5) (b5) catalyze the reduction of sulfamethoxazole hydroxylamine (SMX-HA), which can contribute to sulfonamide hypersensitivity, to the parent drug sulfamethoxazole. Variability in hydroxylamine reduction could thus play a role in adv...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2905818/ https://ncbi.nlm.nih.gov/pubmed/19997042 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e3283343296 |
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